Post-Congress

June 27-28, 2011

Institute of Nuclear Chemistry

Johannes Gutenberg University Mainz

Fritz-Strassmann-Weg 2, 55128 Mainz, Germany

Training School on PET Radionuclide Generators

Ge-68/Ga-68  and Ti-44/Sc-44 

The intention of the training school is to provide theoretical and hands-on know-ledge on the 68Ge/68Ga radionuclide generator mainly, but also on the 44Ti/44Sc radionuclide generator. The 68Ge/68Ga radionuclide generator is increasingly relevant for the development of new molecular imaging probes, both for fundamental research as well as for routine clinical diagnosis using PET/CT. The 44Ti/44Sc radionuclide generator provides a longer-living daughter nuclide with potential for imaging targeting processes of slower biological kinetics and is a source of quantifying individual radiation doses for analogue radiotherapeuticals labelled with trivalent therapeutic radiometals.

The concept of the training school is to combine both theory and practice for several topics, such as generators, generator post-processing, ligands and labelling, automatisation, quality control, GMP and regulatory aspects. To bridge the PET-generators with endoradiotherapy, labelling will be trained with 177Lu in addition.

Commercial companies involved in production of generators and syntheses modules, modules synthesising labelled compounds or in synthesising ligands will demonstrate state-of-the art products. Those are EZAG AG (Berlin), itg (Munich), IDB Holland.

Several generators from these companies and of different types (TiO 2-based, SnO 2-based, organic phase-based) are available and the hands-on training on these generators is provide in small groups of less than 4 participants. In addition, generator and eluate processing as well as synthesis and quality control will be trained using the commercial modules of the companies as well as manual devices.

Participants shall have own background in working with radioactive sources and shall provide own personal radiation dosimeter or adequate documents prior to start hands-on training at the Institute of Nuclear Chemistry of the University of Mainz, Germany.

Only a small number of places will be available for the post-congress training school at the University of Mainz.

Registration

is due to April 30, 2011 and shall be sent to Prof. Dr. Frank Rösch via E-Mail

frank.roesch@uni-mainz.de

Registration Fee:

500 € including coffee breaks, lunch and dinner

Please transfer it until April 30, 2011 to
Name of account owner:    Landeshochschulkasse Mainz

Bank:                                  Deutsche Bundesbank Filiale Mainz
IBAN:                                  DE25 5500 0000 0055 0015 11
BIC:                                    MARKDEF 1550
Please indicate reference as:
For the uses of: 6101 28286 9615029 + YOUR NAME
The registration fee does not cover costs for hotels.

.

Hotel Accomodation

The registration fee does not cover costs for hotels.

Participants intending to leave already June 28 late evening or planning to extend their stay are requested to indicate the according periods at the registration.

We will make hotel reservation for you from Sunday, June 26, 2011 to Wednesday, June 29, 2011. In the case you are leaving on the evening of June 28 already, please indicate. If you are interested in even longer stay, please indicate.

There are two hotels available, one (hotel A) at about 70 € per night including breakfast, the other (Hotel B) 140 €, respectively.

Please contact Prof. Dr. Frank Rösch via E-Mail frank.roesch@uni-mainz.de

From Mainz you may reach Frankfurt International Airport within less than half an hour.

Radiation safety

We urgently ask you to take with you all the official documents and / or dosimeters to make sure that you are eligible to work with radioactive sources. Our radiation safety staff is responsible to check whether you are allowed to work in the hot laboratory. In order to avoid delay at Monday morning, please fax the relevant documents to:

+49 6131 3924692 until May 31, 2011 (Post-Congress_Fax_Form.doc).

Preliminary Programme

 

1st day 8:30 - 18:30

 

 

Introduction

Radiation safety issues

 

Theory

The Ge-68/Ga-68 generator : g8Ge production and generator designs

 

 

Coffee break

 

Laboratory

Generator eluation, Ga-68 Yields, Ge-68 breakthrough

 

 

Lunch

 

Theory

Overview on the post-processing of Ga-68 generator eluates

 

 

Coffee break

 

Laboratory

Generator elutions combined with post-processing technologies

 

 

Dinner: „Theory and praxis of wine tasting“

 

 

2nd day: 09:00 – 18:30

 

 

Theory

Ligands for Ga-68 and Lu-177 and labelling chemistry

 

 

Coffee break

 

Laboratory

Labelling of DOTA-conjugated octreotides including the handling of automated modules

 

 

Lunch

 

Theory

Quality control of Ga-68 and Lu-177-labelled DOTA-octreotides

 

 

Coffee break

 

Laboratory

TLC and HPLC of Ga-68 and Lu-177-labelled DOTA-octreotides

 

 

Round table discussion of results